CHRISTOPH H. GLEITER;WILLIAM H. FREY II;LUSINE DANIELYAN
发明人:
WILLIAM H. FREY II,LUSINE DANIELYAN,CHRISTOPH H. GLEITER
申请号：
SG2012066049
公开号：
SG184724A1
申请日:
2008.09.04
申请国别(地区):
SG
年份:
2012
代理人:
摘要：
ABSTRACTMETHODS, PHARMACEUTICAL COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR ADMINISTERING THERAPEUTIC CELLS TO THE ANIMAL CENTRAL NERVOUS SYSTEMMethods and compositions for preventing and treating the damaged and/or degenerating CNS experiencing loss or death of CNS cells. Various embodiments of the invention transport a therapeutically effective amount of, inter alia, at least one therapeutic cell to the CNS by intranasal application to the upper-third of the nasal cavity, thereby bypassing the blood-brain barrier. A pharmaceutical composition according to the invention may comprise at least one therapeutic cell, at least one delivery-enhancement agent, at least one antibiotic, at least one regulatory factor and/or at least one immunosuppressive agent, wherein the composition is delivered to the upper-third of the nasal cavity. The therapeutic cells, once delivered to the CNS, migrate preferentially to the area of damage or degeneration or injury.No Figure
