NOVEL GOLD(III) COMPLEXES CONTAINING N-HETEROCYCLIC CARBENE LIGAND, SYNTHESIS, AND THEIR APPLICATIONS IN CANCER TREATMENT AND THIOL DETECTION

• 收藏
• 分享

专利权人:

THE UNIVERSITY OF HONG KONG

发明人:

CHE, CHIMING,ZOU, TAOTAO

申请号：

EP13854442

公开号：

EP2920186A4

申请日:

2013.11.15

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

Provided herein is a method of synthesis of Au(III)-NHC complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Au(III)-NHC complexes. Also provided is method of detecting thiol in a biological system. The Au(III)-NHC complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growth in vivo.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/