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Peptidomimetic macrocycles as modulators of MCL-1
专利权人:
AILERON Therapeutics; Inc.
发明人:
Vincent Guerlavais,Eric Feyfant
申请号:
US15259947
公开号:
US10023613B2
申请日:
2016.09.08
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The disclosed peptidomimetic macrocycles modulate the activity of MCL-1. Myeloid cell leukemia 1 (MCL-1) is a protein that inhibits cell death. Peptidomimetic macrocycles, pharmaceutical compositions, and methods disclosed herein can be used for the treatment of disease in which MCL-1 is over-expressed, such as cancer. In particular, MCL-1-modulating peptidomimetic macrocycles disclosed herein can be applied in the setting of resistance to BCL-2 family inhibitors, which is often engendered by MCL-1 over-expression or hyper-activation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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