PROBLEM TO BE SOLVED: To solve such a problem that, though it becomes clear that fibrocyte, or bone marrow-derived leukocyte cell having an ability to produce collagen, involves in a progressing process of the fibrillation of various internal organs such as heart, lung, liver, kidney, and skin, and draws attention, it is still unclear how the fibrocyte involves in the fibrillation of the various internal organs.SOLUTION: Hence it was found that fibrocyte in the kidney involves in the progress of the nephropathy, the method for determining the progress of the nephropathy uses the fibrocyte as a marker. It was found that the density of the fibrocyte in the peripheral blood correlates with the interstitial pneumonia due to collagen diseases, so that an examination method for the interstitial pneumonia due to collagen diseases is found using the fibrocyte as the marker, and renal fibrillation inhibitor containing propagermanium is completed.COPYRIGHT: (C)2012,JPO&INPIT【課題】コラーゲン産生能を有する骨髄由来の白血球系細胞であるfibrocyteが、心臓、肺、肝臓、腎臓および皮膚といった各種臓器線維化の進展過程に関与することが明らかとなり注目されている。しかしながら、fibrocyteが各種臓器の繊維化にどのように関与しているかが不明である。【解決手段】腎におけるfibrocyteは腎症の進展に関与することを見出したことにより、fibrocyteをマーカーとした腎症の進行度の判定方法、末梢血中のfibrocyteの濃度が膠原病性間質性肺炎と相関あることを見出したことにより、fibrocyteをマーカーとした膠原病性間質性肺炎の検査方法、並びに、プロパゲルマニウムを含む腎繊維化抑制剤を完成した。【選択図】なし
