Antibodies for the treatment of HIV

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专利权人:

Pierre Fabre Medicament

发明人:

Klinguer-Hamour, Christine

申请号：

AU2011322508

公开号：

AU2011322508A1

申请日:

2011.10.27

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The present invention relates to isolated antibodies, or the derivatives or antigen binding fragments of same, capable of binding to CXCR4 but also of inducing conformational change of the CXCR4 homodimers and able to inhibit HIV-1 primary isolate replication in PBMC. More particularly, the present invention relates to the 515H7 and 301 aE5 monoclonal antibodies, specific to the CXCR4 protein, as well as their use for the treatment of HIV infection. Pharmaceutical compositions comprising such antibodies and a process for the selection of such antibodies are also covered.

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中国工程科技知识中心

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http://www.ckcest.cn/home/