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Antibodies for the treatment of HIV
专利权人:
Pierre Fabre Medicament
发明人:
Klinguer-Hamour, Christine
申请号:
AU2011322508
公开号:
AU2011322508A1
申请日:
2011.10.27
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
The present invention relates to isolated antibodies, or the derivatives or antigen binding fragments of same, capable of binding to CXCR4 but also of inducing conformational change of the CXCR4 homodimers and able to inhibit HIV-1 primary isolate replication in PBMC. More particularly, the present invention relates to the 515H7 and 301 aE5 monoclonal antibodies, specific to the CXCR4 protein, as well as their use for the treatment of HIV infection. Pharmaceutical compositions comprising such antibodies and a process for the selection of such antibodies are also covered.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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