Tatyana A. Shatova,Klavs F. Jensen,Marissa R. Engle
申请号：
US15399285
公开号：
US20170191982A1
申请日:
2017.01.05
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A portable, microfluidic blood plasma separation device is presented featuring a constriction-expansion design, which can produce up to about 100% purity for undiluted blood at least about 9% yield. This level of purity represents an improvement of at least one order of magnitude with increased yield compared to that achieved previously using passive separation. The system features high flow rates, 5-30 μL/min plasma collection, with minimal clogging and biofouling. The simple, portable blood plasma separation design can be hand-driven and can easily be incorporated with microfluidic or laboratory scale diagnostic assays. The separation system can be used in conjunction with portable analyte detection tests at concentrations well below clinical relevancy for undiluted whole blood.
