BAELL, JONATHAN BAYLDON,BUI, CHINH THIEN,COLMAN, PETER,CZABOTAR, PETER,DUDLEY, DANETTE A.,FAIRBROTHER, WAYNE J.,FLYGARE, JOHN A.,LESSENE, GUILLAUME LAURENT,NDUBAKU, CHUDI,NIKOLAKOPOULOS, GEORGE,SLEEBS
申请号：
PE0012542011
公开号：
PE03342012A1
申请日:
2009.12.17
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to a compound of formula I, where q is co - CH2 -, - ch (RA) -, - C (RA) 2 - ra is c1-c4 alkyl, haloalquilo c1-c4 r1 is, IF present, halogen or alkyl = C1, C1 - C6, haloalquilo - C6, among others and X1c X1B X1a, are each CH, N, C (OH), C (NH2), among others x1d is absent or, or - NH, N - (c1-c4 alkyl) -,N (C (o) c1-c4 alkyl) M is 1 - 2 n is 2 - 3 is Preferred benzo [d] thiazole b is preferably acid 2 (1H) - thiazole - 4 - carboxylic acid l is absent or Blender (arilen C6 C10) (heteroalquileno C1 - C6), heteroalquileno C1 - C6, haloalquileno C1 - C6, - NH -, S, among others, and is preferably h, halogen.Preferred compounds are: Acid 2 - (4 - (benzo [d] thiazole - 2 - ilcarbamoil) - 3,4 - dihidroidoquinolin - 2 (1H) - yl) - 5 - (3 - (3 - (terbutoxicarbonilamino) phenoxy) propyl) thiazole - 4 - carboxylic acid 2 - (4 - (benzo [d] thiazole 2ilcarbamoil) - 3,4 - dihidroisoquinolin - 2 (1H) - yl) - 5 - (3 - (4 - (1 - fenilciclopentil) phenoxy) propyl) - 4 - carb thiazole Oxilico among others.These compounds are inhibitors of a type or subset of antiapoptotic bcl-2 Proteins are useful in the treatment of different types of cancerREFERIDA A UN COMPUESTO DE FORMULA I, DONDE Q ES -CO, -CH2-, -CH(Ra)-, -C(Ra)2- Ra ES ALQUILO C1-C4, HALOALQUILO C1-C4 R1 ES, SI ESTA PRESENTE, HALOGENO, =O, ALQUILO C1-C6, HALOALQUILO C1-C6, ENTRE OTROS X1a, X1b Y X1c SON CADA UNO CH, N, C(OH), C(NH2), ENTRE OTROS X1d ESTA AUSENTE O ES O, -NH, -N(ALQUILO C1-C4)-, -N(C(O)ALQUILO C1-C4) m ES 1-2 n ES 2-3 A ES DE PREFERENCIA BENZO[d]TIAZOL B ES DE PREFERENCIA ACIDO 2(1H)-TIAZOL-4-CARBOXILICO L ESTA AUSENTE O ES LIGADOR (ARILEN C6-C10)-(HETEROALQUILENO C1-C6), HETEROALQUILENO C1-C6, HALOALQUILENO C1-C6, -NH-, S, ENTRE OTROS E ES DE PREFERENCIA H, HALOGENO. SON COMPUESTOS PREFERIDOS: ACIDO 2-(8-(BENZO[d]TIAZOL-2-ILCARBAMOIL)-3,4-DIHIDROIDOQUINOLIN-2(1H)-IL)-5-(3-(3-(TERBUTOXICARBONILAMINO)FENOXI)PROPIL)TIAZOL-4-CARBOXILICO ACIDO 2-(8-(BENZO[d]TIAZOL-2ILCARBAMOIL)-3,4-DIHIDROISOQUINOLIN-2(1H)-IL
