DI FRANCESCO, Maria, Emilia,ZANG, Zhijun,JONES, Philip,HEFFERNAN, Timothy,SOTH, Michael, P.,LE, Kang,CARROLL, Christopher, Lawrence,MCAFOOS, Timothy,BURKE, Jason, P.,THEROFF, Jay
申请号：
USUS2015/039143
公开号：
WO2016/004413A3
申请日:
2015.07.02
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
Disclosed herein are compounds and compositions useful in the treatment of GLS I mediated diseases, such as cancer, having the structure of Formula I. Methods of inhibition GLS I activity in a human or animal subject are also provided. Accordingly, the inventors herein disclose new compositions and methods for inhibiting glutaminase activity.Linvention concerne des composés et des compositions utiles dans le traitement de maladies médiées par la GLS1, telles que le cancer, possédant la structure de formule I. Linvention concerne également des procédés dinhibition de lactivité de la GLS1 chez un sujet humain ou animal.
