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Cyclic triazo sodium channel blocker
专利权人:
ユニバーシティ オブ グリニッジ
发明人:
リーチ、マイケル,フランツマン、カール,リドール、ディーター,ハーバイジ、ローレンス
申请号:
JP2012519066
公开号:
JP5847079B2
申请日:
2010.07.08
申请国别(地区):
JP
年份:
2016
代理人:
摘要:
The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The triazine compounds are of formula (I) wherein: R1 is hydrogen or a substituent group; R2 is amino or a substituent group; N* is amino when R1 is hydrogen or ═NH when R1 is a substituent group; R3 and R4 are both carbocyclic, heterocyclic or alkyl groups and may be same or different; and R5 is hydrogen, alkyl or a cyclic aryl group, with the proviso that: when R3 and R4 are both alkyl they are linked to form a cycloalkyl group, and R5 is a cyclic aromatic group; and when R3 and R4 are both carbocyclic or heterocyclic groups, R5 is hydrogen or an alkyl group; or a salt thereof.
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