An intravascular port access device includes a first component having a chamber configured to attach reversibly to an intravenous line port. A second component reversibly attaches to the first component and contains a disinfecting agent and an applicator material. The second component is configured to be reversibly received over external surfaces of the intravenous line port. A method of cleansing an intravenous line port includes providing a port cleaning device having a first component with a chamber containing a first cleaning agent. A second component includes a second cleaning agent. A third component has a microbiocidal agent and is reversibly attached to the first component. The second component is removed from the device, the external surfaces of the port are contacted with the second cleaning agent, the first cleaning agent is ejected from the chamber into the port, and the third component is used to cap the port.本發明提供一種血管內出入口進入裝置，其包括一具有一腔室之第一組件，該第一組件經組態以逆向地附接至一靜脈內導管出入口。一第二組件逆向地附接至該第一組件，且包含消毒劑及塗藥器材料。該第二組件經組態以被逆向地收納於靜脈內導管出入口之外部表面上方。本發明亦提供一種淨化一靜脈內導管出入口之方法，其包括提供一出入口清潔裝置，該出入口清潔裝置具有一第一組件，該第一組件具有一含有第一清潔劑之腔室。一第二組件包括第二清潔劑。一第三組件具有殺菌劑，且逆向地附接至該第一組件。自該裝置移除該第二組件，使該出入口之外部表面與該第二清潔劑接觸，將該第一清潔劑自該腔室排出至該出入口中，且使用該第三組件來封蓋該出入口。
