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Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing CG motifs
专利权人:
Guido Grandi
发明人:
Guido Grandi,Rino Rappuoli,Marzia M. Giuliani,Mariagrazia Pizza
申请号:
US09914454
公开号:
US08221761B1
申请日:
2000.02.09
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Immunogenic compositions (e.g. vaccines) comprising: (a) an immunostimulating amount of a Neisseria antigen (preferably N. meningitidis serogroup B) and (b) an immunostimulating amount of an adjuvant composition comprising an oligonucleotide comprising at least one CG motif. Component (b) may further comprise a second adjuvant. Component (a) may be selected from a variety of antigens. Adjuvant compositions comprising an oligonucleotide having at least one CG motif, and complete Freunds adjuvant (CFA) are also provided.
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