A compound of formulas II, III, IV, or V: ** ** Formula or a pharmaceutically acceptable salt thereof, wherein: 5 is a single or double bond R1 is hydrogen or C1-6 aliphatic optionally substituted: -L2-A1-L1- is -OCH2CH2-, -CH> = CHCH 2, or -C≡C-CH2- or -L2-A1-L1 is -O-C2, C3 alkenylene, or alkynylene C3, optionally substituted or -L2-A1-L1 is one of the following: ** ** Formula wherein ring B is a 5-membered heteroaryl ring having 1-3 heteroatoms selected from nitrogen, oxygen, and sulfur, and ring C is a 6-membered heteroaryl ring having 1-3 nitrogens that or -L2-A1-L1 is one of the following: ** ** Formula wherein ring B is a 5-membered heteroaryl ring having 1-3 heteroatoms selected from nitrogen, oxygen, and sulfur, and ring C is a 6-membered heteroaryl ring having 1-3 nitrogens that or -L2-A1-L1 is one of the following: ** ** Formula ring A 2 is a monocyclic carbocyclic ring of 3-7 membered, saturated or unsaturated PAR15 tially, a carbocyclic ring bicyclic 7-10 membered saturated or partially unsaturated, monocyclic heterocyclic ring of 4- 7 members saturated or partially unsaturated, having 1-2 independently nitrogen, oxygen or sulfur, a bicyclic heterocyclic ring 7-10 membered saturated or partially unsaturated heteroatoms selected having 1 -3 heteroatoms independently selected from nitrogen, oxygen or sulfur, a phenyl ring, a bicyclic ring 8-10 membered aryl, a heteroaryl ring 5-6 membered monocyclic having 1-3 heteroatoms independently selected from nitrogen, oxygen or sulfur, a bicyclic heteroaryl ring having 1-4 8-10 membered heteroatoms independently selected from nitrogen, oxygen or sulfur, or a tricyclic ring 10-16 membered saturated, partially unsaturated or aromatic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, wherein the ring A2 is optionally substituted with 1-4 groups Rx each Rx is independently -R, alkylidenyl optionally substituted oxo, halo, -NO2, -CN, -OR, -SR, - N (R ) 2, -C (O) R, -CO2R, -C (O ) C (O)
