Combination of prostaglandins and derivatives for glaucoma treatment and / or reduction of intraocular pressure and their use. Ophthalmic drugs for the treatment of glaucoma, high intraocular pressure and other ophthalmic diseases. These components include an effective amount of prostate hormone or proprioception. 1. Characteristic 1: ophthalmic drug ingredients for glaucoma treatment and intraocular pressure control, including an effective amount of a formula compound (1),A select (2) from the formula group compounds,1. Imina, sidnominina, oxima, hydroxypropidine, n-hydroxyguandine or hydroxyurea； and a vehicle acceptable for drugs； 11. Claim 11: claim method 9, comprising a plurality of glaucoma therapeutic agents. 11. Claim 12: method of claim 11, in which at least one glaucoma treatment agent is selected from group B, including blocker B, prostaglandin analogue, carbonatase inhibitor, agent a8322；miotics, rho kinase inhibitors, serotonergic agonists and neuroprotectors. Claim 15: The compound of claim 11, which is selected from: (Z) -7 - ((1R, 2R, 3R, 5S) -3,5-bis (nitrooxy) -2 - ((R, E) - 3- (nitrooxy) -4- (3- (trifluoromethyl) phenoxy) but-1-en-1-yl) cyclopentyl) isopropyl hept-5-enoate and (Z) -2 - (((( Z) -7 - ((1R, 2R, 3R, 5S) -3,5-dihydroxy-2 - ((R, E) -3-hydroxy-4- (3- (trifluoromethyl) phenoxy) but-1-en -1-yl) cyclopentyl) hept-5-enoyl) oxy) methoxy) -1- (pyrrolidin-1-yl) diazene.Conjugados de prostaglandina y derivados, y métodos para su uso, para tratar el glaucoma y/o reducir la presión intraocular. Composiciones farmacéuticas oftálmicas útiles en el tratamiento de enfermedades oculares como el glaucoma y la presión intraocular elevada. Dichas composiciones comprenden una cantidad eficaz de conjugados de prostaglandina o derivados de la presente. Reivindicación 1: Una composición farmacéutica oftálmica útil en el tratamiento del glaucoma y en el control de la presión intraocular, que comprende una cantidad eficaz de un compuesto de la fórmula (1), don
