Thomas Muster,Ekaterina Romanovskaya-Romanko,Oleg Kiselev,Markus Wolschek,Boris Ferko,Andrej Egorov
申请号：
US15655306
公开号：
US20180016560A1
申请日:
2017.07.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides a novel influenza virus wherein both the NS and the PB1 gene segments are modified and wherein the PB1-F2 open reading frame is modified by introduction of at least one stop codon. Specifically, the influenza virus is lacking functional NS1 and PB1-F2 proteins. Additionally, a vaccine formulation comprising said modified influenza virus is provided and its use for prevention of influenza infection.
