Systems and methods for monitoring and controlling activities of Drosophila organisms are provided. In one aspect, a method includes acquiring, using a first activity detector, imaging data tracking movements of the Drosophila organisms, and acquiring, using a second activity detector, bioluminescence data corresponding to a neural activity of the Drosophila organisms. The method also includes correlating, using the acquired data, a behavioral activity and neural activity of the Drosophila organisms, and determining, using the correlation, an activity profile for the Drosophila organisms. The method further includes providing, based on the activity profile, a stimulation to the Drosophila organisms to control at least one of the behavior activity or the neural activity over a time period extendible to a nominal life cycle of the Drosophila organisms.
