Compositions having a mixture of lidocaine, prilocaine and tetracaine, or their pharmaceutically acceptable salts. A preferred composition includes the following components in the indicated approximate w/w percentages: 1.5% lidocaine base； 1.5% prilocaine base； 4% tetracaine base and water. In some implementations, also included may be about 10% methylpynrolidone； 2% dimethyl sulfoxide； 0.08% topical hyaluronidase； 1.5% guar gum； 1% polyoxyethylenesorbitan monolaurate； 0.5 polyoxyethylenesorbitan monooleate, and water to 100%. Such compositions exhibits a high concentration on skin, a deep anesthetic effect and a significantly more rapid onset of the anesthetic effect than comparable transdermal anesthetics.
