REIC-expressing adenovirus vector

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专利权人:

Hiromi Kumon

发明人:

Hiromi Kumon,Namho Huh,Masakiyo Sakaguchi,Masami Watanabe

申请号：

US14119772

公开号：

US09222107B2

申请日:

2012.05.25

申请国别(地区):

US

年份:

2015

代理人:

摘要：

An objective of the present invention is to provide an adenovirus vector expressing a REIC/Dkk-3 protein at a high level and containing a DNA construct for expression of REIC/Dkk-3 DNA, wherein the DNA construct is prepared by ligating, from the 5′ terminal side,(i) a CMV promoter,(ii) REIC/Dkk-3 DNA,(iii) a polyA addition sequence, and(iv) enhancers prepared by linking an hTERT (Telomerase Reverse Transcriptase) enhancer, an SV40 enhancer, and a CMV enhancer in this order.

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