KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;경북대학교 산학협력단
发明人:
CHANG YONG MIN,장용민,KIM HEE KYEONG,김희경
申请号：
KR1020190027841
公开号：
KR1020190111768A
申请日:
2019.03.12
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to a compound, and an anti-inflammatory agent, a cyclooxygenase-2 inhibitor, a brain disease treatment agent, and an MRI contrast agent containing the compound. The compound of the present invention has a structure represented by chemical formula 1, in which linker represents *-(CH_2)_x-A-(CH_2)_y-*； each of x and y independently represents any one integer of 0 to 5； A represents *-COO-*, *-CO-*, *-CONH-* or *-O-*； and X represents aa, bb or cc. The present invention can be used as anti-inflammatory agent and COX-2 selective inhibitor capable of targeting and diagnosing inflammation of inflammatory diseases and at the same time, treating the same.COPYRIGHT KIPO 2020본 발명의 화합물, 이를 포함하는 항염증제, 시클로옥시게나아제-2 억제제, 뇌질환 치료제, 및 MRI 조영제에서, 본 발명의 화합물은 하기 화학식 1로 나타내는 구조를 갖는다.[화학식 1]상기 화학식 1에서,Linker는 *-(CH2)x-A-(CH2)y-*를 나타내고,x 및 y는 각각 독립적으로 0 내지 5 중 어느 하나의 정수를 나타내며,A는 *-COO-*, *-CO-*, *-CONH-* 또는 *-O-*를 나타내고,X는 , 또는 를 나타낸다.
