AJAY PUROHIT,Thomas d harris,HEIKE S RADEKE,SIMON P ROBINSON,MING YU,DAVID S CASEBIER,MICHAEL T AZURE
申请号：
IN201618009021
公开号：
IN201618009021A
申请日:
2016.03.15
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
A compound having Structure Delta as follows: or a salt thereof, wherein: linking groups B, D, E, F, and G are independently selected from the group consisting of a bond, alkyl, aryl, aralkyl, alkylaryl, heteroaryl, alkoxy, alkylamino, aminoalkyl, aryloxy, alkoxyalkyl, thioalkyl, and heterocyclyl R8 through R14 are independently selected from the group consisting of H, OR3, F, Cl, Br, I, CH2F, OCH2CH2F, alkyl (C1-C4), aryl, heteroaryl, C(=O)R3, CO2R3, and imaging moiety (Im) R3, R4, R5, and R6 are independently selected from the group consisting of H, alkyl, aryl, aralkyl, heteroaryl, alkylamino, alkyloxy, and aryloxy optionally any two of R4, R5, R6, R13, or R14 may form a cyclic structure selected from the group consisting of a bond, -CH2-, -CH2-CH2-, -CH2-CH2-CH2-, -CH=CH-, -X=CH-, and -X-CH=CH- X is selected from the group consisting of O, NH, N=, and NR7, and R7 is selected from the group consisting of alkyl, aryl, and heteroaryl substituents and wherein an Im may be present in either R3-R7 and provided at least one Im is present, said imaging moiety (Im) being selected from the group consisting of 18F, 76Br, 124I, 131I, 99mTc, 153Gd, and 111In and provided that when any one of R8-R12 is an imaging moiety (Im), the linking group B, D, E, F, or G which attaches the imaging moiety to the phenyl ring contains at least one atom.
