АБДЕЛЬМАГИД Омар Йусиф (US),БРИКЕР Джозеф Майкл (US),ШИЛДС Шелли Линн (US),ГЭЛВИН Джеффри И. (US)
申请号：
RU2013136151/10
公开号：
RU2013136151A
申请日:
2012.02.03
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. Immunogenic composition containing Bordetella bronchiseptica and isolated pertactin antigen. 2. The immunogenic composition of claim 1, wherein said pertactin antigen is a Bordetella bronchiseptica protein. The immunogenic composition of claim 2, wherein said pertactin antigen is a p68.4 recombinant protein. The immunogenic composition of claim 1, wherein Bordetella bronchiseptica is a bacterium or bacterial extract. The immunogenic composition according to claim 1, which is not adjuvant. The immunogenic composition according to claim 1, wherein said pertactin antigen is present in an amount of from about 1 μg to about 30 μg. The immunogenic composition according to claim 1, wherein said pertactin antigen is obtained by solubilizing the bodies of pertactin inclusions in urea, and essentially not containing aggregates of pertactin antigens. The immunogenic composition of claim 1, wherein the pertactin antigen is lipidated. The immunogenic composition of claim 1, further comprising a diluent or excipient for parenteral administration to the dog. The immunogenic composition of claim 1, further comprising an isolated Bsp22 antigen, which is possibly lipidated. The immunogenic composition according to any one of claims 1 to 10, further comprising an antigen from a canine respiratory pathogen selected from the group consisting of the following: canine parainfluenza virus (CPIV), canine adenovirus-2 (CAV-2), canine respiratory coronavirus (CRCoV) , Mycoplasma cynos (M. cynos) and canine influenza virus (CIV) .12. An immunogenic composition according to claim 11, containing at least two, three or four antigens from a canine respiratory pathogen. The immunogenic composition according to claim 11, containing antigens �1. Иммуногенная композиция, содержащая Bordetella bronchiseptica и выделенный пертактиновый антиген.2. Иммуногенная композиция по п.1, где указанный пертактиновый антиген представляет собой белок Bordetella bronchiseptica.3. Иммуногенная композиция по п.2, гд
