#$%^&*AU2011250793B220121129.pdf#####ABSTRACT Compositions useful for improving effectiveness of alpha2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid in solubilizing the alpha-2-adrenergic agonist components. In one embodiment, the alpha-2-adrenergic agonist components include alpha-2-adrenergic agonists. In another embodiment, the solubility enhancing components include povidone or ployvinyl alcohol. Documem29 - 14/11/1