CHEN, CHIH-KUANG,陈志光,陳志光,LEE, JING-YI,李静宜,李靜宜,LU, WEI-SHU,卢威书,盧威書,BROWN, CARL OSCAR III,周 步朗,周 步朗
申请号：
TW105126278
公开号：
TW201717927A
申请日:
2016.08.17
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
Methods and compositions for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex by using diacerein or its analogs are provided. Also provided are methods and compositions for the treatment and/or prevention of a disorder mediated by ASC and/or NLRP3, and/or by formation of NLRP3 inflammasome complex by using diacerein or its analogs.提供使用雙醋瑞因或其類似物抑制ASC表現、NLRP3表現、以及/或NLRP3發炎體複合物的形成之方法與組成物。並提供使用雙醋瑞因或其類似物治療以及/或預防由ASC以及/或NRLP3、及/或NLRP3發炎體複合物的形成所介導的疾病之方法及組成物。
