Targeting pathogenic monocytes

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专利权人:

エックスバイオテク，インコーポレイテッド;エックスバイオテク,インコーポレイテッド

发明人:

シマール，ジョン,シマール,ジョン

申请号：

JP2011527020

公开号：

JP5976319B2

申请日:

2009.09.14

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

The invention is based on the discovery that interleukin-1 alpha (IL-1alpha) is expressed on the proinflammatory CD14+CD16+ monocyte subset. Importantly, since IL-1alpha appears to be almost exclusively expressed on this monocyte subset and not other leukocytes, it represents an ideal marker for targeting the CD14+CD16+ monocyte subset. The effectiveness of an agent that depletes such pathogenic cells or modulates IL-1alpha function on such cells type can be monitored by assessing CD14+CD16+ monocyte levels or functionality.

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中国工程科技知识中心

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