The invention relates to newly identified peptides of that are capable of inducing tolerance to cow's milk, especially to B-lactoglobulin. The peptides may be administered to mammals, especially to young infants who are at risk of allergy to cow's milk proteins, to induce oral tolerance to cow's milk； they may also be administered to children or adults who are allergic to cow's milk to allow "desensitization" towards the allergenic milk proteins, especially B-lactoglobulin, to occur. The peptides may also be used to induce tolerance to goat's and buffalo's milk proteins, especially B-lactoglobulin. The peptides are capable of modulating the mammalian immune response to allergens.
