High, Katherine A.;Sabatino, Denise;The Children's Hospital of Philadelphia;Elkouby, Liron
发明人:
申请号：
EP15832128.1
公开号：
EP3180022A4
申请日:
2015.08.13
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Factor VIII variants and methods of use thereof are disclosed. In particular embodiments, Factor VIII variants are expressed more efficiently by cells over wild-type Factor VIII proteins, are secreted at increased levels by cells over wild-type Factor VIII proteins, exhibit enhanced activity over wild-type Factor VIII proteins and are packaged more efficiently into viral vectors.
