Padmanabh Chivukula,Steven P. Tanis,Joseph E. Payne
申请号：
US15788742
公开号：
US10487105B2
申请日:
2017.10.19
申请国别(地区):
US
年份:
2019
代理人:
摘要：
What is described is a trinucleotide cap analog comprising m7G(5′；)p3-N1pN2 for increased efficiency of in vitro transcription of m7G(5′；)p3-RNA, wherein m7G is N7-methylguanosine or analog, (5′；)p3 is a 5′；,5′；-triphosphate bridge, and N1 or N2 or both ribonucleotide analogs linked to each other by a phosphate, p, and wherein the trinucleotide cap analog increases the efficiency of in vitro transcription.
