Joseph SODROSKI,Navid MADANI,Amy M. PRINCIOTTO,Arne SCHON,Judith M. LaLONDE,Ernesto FREIRE,Amos B. SMITH,Richard T. WYATT,Jongwoo PARK,Joel R. COURTER,David M. JONES,Wayne A. HENDRICKSON,Xueling WU,Ma
申请号：
US15117866
公开号：
US20160362478A1
申请日:
2015.02.10
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Described herein are methods of generating a protein binding domain that specifically binds to gp120 in a specific conformational state, comprising contacting gp120 with a CD4-mimetic compound, thereby forming gp120 in the specific conformational state and generating antibodies to gp120 in the specific conformation state. Relatedly, the disclosure also describes methods of neutralizing HIV-1, comprising contacting HIV-1 with an effective amount of a CD4-mimetic compound, thereby forming HIV-1 having gp120 in a specific conformational state and contacting the HIV-1 in the specific conformational state with an antibody.
