Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer 14 and transporting it to a receiver 54 is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution 12, transporting the aqueous solution through a fluid path system 44 out of the polarizer, filtering the aqueous solution through a partical size exclusion filter 54 to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial 28 for containing a hyperpolarized imaging agent therein, a dissolution fluid path 36, a delivery fluid path 44 , a particle size exclusion filter 54 ,and a receiver 55 connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.
