Embodiments can provide a real-time fatigue monitoring system for detecting and/or monitoring a fatigue condition of a driver of a driving apparatus. In some embodiments, the fatigue monitoring system can include a set of one or more sensors for detecting a physiological condition of the driver, a head movement detection device, one or more processing devices, and/or any other components. In some embodiments, the fatigue condition detection system may include a processing device configured to determine occurrence of a fatigue condition in response to the detection of a physiological condition of the driver is below a threshold while the driver's head movement is tilting downwards.