A system and method for inter¬facing non-sterile sensors to a sterile flow stream is disclosed. Typically, sensors cannot be sterilized in the same manner as other com¬ponents of the flow stream. This results in com¬plex processes to incorporate a sterilized sensor into a sterilized flow stream. By introducing a separation membrane, the desired sensor can be interfaced to the sterile flow stream. By doing so, the sensor need not be sterile, only suffi¬ciently clean. The membrane separates the ster¬ile environment within the flow stream from the sensor, while still permitting the sensor to func¬tion.