The present invention relates to the treatment of osteoarthritis in a human subject using anti-IL-1[alpha] and anti-IL-1[beta] DVD-Ig proteins. In various embodiments, the osteoarthritis includes knee osteoarthritis or hand osteoarthritis.本發明係關於使用抗IL-1α及抗IL-1β DVD-Ig蛋白質治療人類個體之骨性關節炎。在各種實施例中,骨性關節炎包括膝骨性關節炎或手骨性關節炎。