POLINENI, Venu,URREA, Alejandro Calderón,POLACK, Glenda W
申请号：
WO2018IB51784
公开号：
WO2018167734(A3)
申请日:
2018.03.17
申请国别(地区):
世界知识产权组织国际局
年份:
2018
代理人:
摘要：
The present invention provides a synergistic composition of a nematicide comprising of a nematicidal peptide, and chalcones, wherein the nematicidal peptide is derived from CED-4 protein sequence is either, Peptide 2, or Peptide 3, or Peptide 12; and chalcones are either chalcone 17, chalcone 25, or chalcone 30. The nematicidal peptides alone show 100 % nematicidal activity at a concentration of 1 mg/ml, whereas, when combined with chalcones, 100 % nematicidal activity is seen at concentration as low as 0.8 mg/ml binging a synergistic effect. Another embodiment of the invention provides a method for preparing working solutions of chalcones in aqueous solvents such as water by diluting the stock solution of chalcones, prepared in dimethyl sulfoxide, serially in ethanol and water. The final concentration of chalcone is around 10-4 -10-5 M in the nematicidal composition. This synergistic nematicidal composition is environmentally safe and non-toxic to humans and animals.
