Jason Baum,Bryan Johnson,Alexey Alexandrovich Lugovskoy,Lihui Xu,Neeraj Kohli,Jonathan Basil Fitzgerald,Sharlene Adams
申请号：
US15248562
公开号：
US09938346B2
申请日:
2016.08.26
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided are monospecific and bispecific antibodies that are useful as anti-neoplastic agents and that bind specifically to human IGF-1R and human ErbB3. Exemplary antibodies inhibit signal transduction through either or both of IGF-1R and ErbB3. Exemplary polyvalent proteins comprise at least one anti-IGF-1R binding site and at least one anti-ErbB3 binding site. In certain embodiments the binding sites may be linked through an immunoglobulin constant region. AntiErbB3 and anti-IGF-1R antibodies (e.g., monoclonal antibodies) are also provided.
