Spiro-oxindole compounds and their uses as therapeutic agents

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专利权人:

Xenon Pharmaceuticals Inc.

发明人:

Chafeev, Mikhail,Chakka, Nagasree,Kamboj, Rajender,Bagherzadeh, Mehran Seid,Hsieh, Tom,Chowdhury, Sultan,Sun, Jianyu,Hou, Duanjie,Liu, Shifeng,Raina, Vandna,Fraser, Robert,Sun, Shaoyi,Fu, Jianmin,Svir

申请号：

AU2006235593

公开号：

AU2006235593B2

申请日:

2006.04.11

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R, R, R, R, R, R, R, R, and R are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof； or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

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中国工程科技知识中心

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http://www.ckcest.cn/home/