Provided is a stable pharmaceutical composition containing ibuprofen and scopolamine butylbromide. A pharmaceutical composition comprising the following components (A), (B) and (C): (A) ibuprofen; (B) scopolamine butylbromide; and (C) at least one compound selected from the group consisting of a basic compound having an acid-neutralizing ability, a xanthine derivative, tranexamic acid or a salt thereof, acetaminophen and an isovalerylurea derivative.