MOLÉCULE CIBLE À LAQUELLE UN AMYLOSPHÉROÏDE SE LIE ET INDUIT LA MORT DE CELLULES NEURONALES MATURES, PROCÉDÉ ET SUBSTANCE POUR L'INHIBITION DE LA MORT DE CELLULES NEURONALES INDUITES PAR AMYLOSPHÉROÏDE, ET UTILISATIONS DE LADITE MOLÉCULE CIBLE, DUDIT PROCÉDÉ ET DE LADITE SUBSTANCE
In one or a plurality of embodiments, there is provided a target molecule of amylospheroid, which is expressed in mature neurons and to which the amylospheroid binds to induce death of cells. Further, in one or a plurality of embodiments, there is provided a method and a substance for inhibiting death of mature neurons induced by the amylospheroid. In one aspect, the present disclosure relates to a use of Na + /K + -ATPase ±3 as a binding target molecule of amylospheroid. In another aspect, the present disclosure relates to a method for suppressing death of mature neurons induced by the amylospheroid, including inhibiting protein-protein interaction between the amylospheroid and the Na + /K + -ATPase ±3, and the like.
