KO JIN YOUNG,KIM JI YEON,PARK SO HYUN,AN SUNG WON,KI MIN HYO
申请号：
NZ62216512
公开号：
NZ622165A
申请日:
2012.08.28
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed herein is a sustained release lipid pre-concentrate, comprising: a) a sorbitan unsaturated fatty acid ester having a polar head with at least two or more -OH (hydroxyl) groups represented by the formula I, where R1 is OH, R2 is OH or an unsaturated C4-30 alkylester and R3 is an unsaturated C4-30 alkylester b) a phospholipid and c) a liquid crystal hardener, free of an ionizable group, having a hydrophobic moiety of 15 to 40 carbon atoms with a triacyl group or a carbon ring structure, wherein the lipid pre-concentrate exists as a liquid phase in the absence of aqueous fluid and forms into a liquid crystal in the presence of aqueous fluid. Also disclosed is a pharmaceutical composition comprising the pre-concentrate as well as a pharmacologically active ingredient.
