Murielle Marie Ellison;Randy Ira Hecht;Mark Leo Michaels;Jeonghoon Sun;Yue-Sheng Li;Agnes Eva Hamburger;Edward John Belouski;Jing Xu
发明人:
Edward John Belouski,Murielle Marie Ellison,Agnes Eva Hamburger,Randy Ira Hecht,Yue-Sheng Li,Mark Leo Michaels,Jeonghoon Sun,Jing Xu
申请号：
US13463731
公开号：
US08618053B2
申请日:
2012.05.03
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides a multimer comprising at least a first and a second chain, the first chain comprising the polypeptide of SEQ ID NO:4, wherein the leucine at position 98 is substituted with an arginine； the proline at position 171 is substituted with glycine； and the alanine at position 180 is substituted with glutamic acid； a linker sequence comprising SEQ ID NO:31； and an Fe domain comprising SEQ NO:11； and a second chain comprising the polypeptide of SEQ ID NO:4, wherein the leucine at position 98 is substituted with an arginine； the proline at position 171 is substituted with glycine； and the alanine at position 180 is substituted with glutamic acid； a linker sequence comprising SEQ ID NO:31； and an Fe domain comprising SEQ ID NO:11, nucleic acids encoding the multimer, pharmaceutical compositions comprising the multimer and methods for treating metabolic disorders using such nucleic acids, multimers or pharmaceutical compositions.
