Systems and methods are provided for determining a system response for a neuronal region of interest (ROI). The method comprises positioning an electrode proximate to the neuronal ROI. The electrode is electrically coupled to a neurostimulation (NS) system. The system delivers, from the NS system, a stimulation waveform from the electrode based on NS parameters. The system further programs one or more processors for: measuring an evoked potential waveform resulting from the stimulation waveform comparing at least one excitation pulse within the stimulation waveform to the evoked potential waveform to obtain a candidate response function repeating the delivering, measuring and comparing operations to obtain a collection of candidate response functions and identifying a neuronal system response for the neuronal ROI based on the collection of candidate response functions.
