BODIL VAN NIEL, Monique,FAUBER, Benjamin,GAINES, Simon,GOBBI, Alberto,RENE, Olivier,VESEY, David,WARD, Stuart
申请号：
ES13735278
公开号：
ES2612165T3
申请日:
2013.07.11
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: m is the number 0 or 1； n is the number 0 or 1； p is a number from 0 to 3； q is the number of 0, 1 or 2； r is a number from 1 to 3； A is: a link； - (CRjRk) t-； -C (O) - (CRjRk) t-； - (CRjRk) t-C (O) -； -NRa- (CRjRk) t-； - (CRjRk) t-NRa-； -C (O) NRa- (CRjRk) t-； - (CRjRk) t-NRaC (O) -； -O- (CRjRk) t-； - (CRjRk) t-O-； -S- (CRjRk) t-； - (CRjRk) t-S-； -SO2- (CRjRk) t-； or - (CRjRk) t-SO2-； t is a number from 0 to 4； W is: -CRbRc-； -OR-； -S-； -SO2-； or -NRd-； one of X1, X2, X3 and X4 is N and the others are CRe； or two of X1, X2, X3 and X4 are N and the others are CRe； or three of X1, X2, X3 and X4 are N and the remainder is CRe； or each of X1, X2, X3 and X4 is CRe； Cast-； -S-； SO2-； -CRfRg-； or -NRh-； Z is: CH； or N； R1, R2, R3, R4, R5, R6, R7 and R8 independently of each other are: hydrogen； or C1-6 alkyl, which may be unsubstituted or substituted once or several times by halogen； or R3 and R4 together with the atom to which they are attached can form an ethylene group； or R3 and R4 together with the atoms to which they are attached can form a saturated or partially saturated ring of three, four, five, six or seven links, which may optionally include one or two heteroatoms chosen from -O-, -NRa- and -S-, and which may be optionally substituted once or several times by Ri； or R5 and R6 together with the atoms to which they are attached can form a saturated or partially saturated ring of three, four, five, six or seven links, which may optionally include one or two heteroatoms chosen from -O-, -NRa- and -S-, and which may be optionally substituted once or several times by Ri； or R7 and R8 together with the atoms to which they are attached can form a saturated or partially saturated ring of three, four, five, six or seven links, which may optionally include one or two heteroatoms chosen from -O-, -NRa- and -S-, and which may be optionally substituted once or several times by
