KEHRY, MARILYN,KING, DAVID J.,DA SILVA CORREIA, JEAN
申请号：
CA2981520
公开号：
CA2981520A1
申请日:
2016.04.01
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein encoded by the T Cell Immunoglobulin and Mucin Protein-3 (??-3). The invention provides a TIM-3-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the TIM-3-binding agent to treat a disorder or disease that is responsive to TIM-3 inhibition, such as cancer, an infectious disease, or an autoimmune disease.
