OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU "PHARMENTERPRISES"
发明人:
NEBOLSIN, VLADIMIR EVGENIEVICH,RYDLOVSKAYA, ANASTASIA VLADIMIROVNA,KROMOVA, TATYANA ALEXANDROVNA
申请号：
CA3046196
公开号：
CA3046196A1
申请日:
2018.05.24
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention relates to chemistry of organic substances, pharmacology and medicine, and concerns treating diseases associated and with aberrant activity of cells of the immune system, more particularly for treating lung, respiratory tract and abdominal diseases, radiation sickness, pain syndrome and other diseases by using compounds of formula (A), wherein R1 is a -C(O)-R2-C(O)- or -R2-C(O)- group, where R2 is a -(CH2)n- group optionally substituted with one or two C1-C6 alkyls, or phenyl, and n is an integer from 0 to 4； wherein the compounds are selected from a group consisting of the compounds as set out in the description. These compounds, as well as pharmaceutically acceptable salts thereof, are highly effective in inhibiting glutaminyl cyclase, which is involved, in particular, in post-translational modification of chemokines and chemotaxis of monocytes, macrophages and other cells of the immune system. This invention also relates to pharmaceutical compositions comprising a therapeutically effective amount of the compounds of formula (A) as defined above.
