The present invention provides compositions comprising nanoparticles comprising (a) a hydrophobic drug, (b) an albumin, and (c) a bioactive polypeptide. The present invention also provides method of making compositions comprising nanoparticles comprising (a) a hydrophobic drug, (b) an albumin, and (c) a bioactive polypeptide. Further provided are methods of use, pharmaceutical compositions, medicines, and kits thereof.