D. James Morre,Brandon Eugene Hostetler,James Jinpal Kim
申请号：
US15205830
公开号：
US09739782B2
申请日:
2016.07.08
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Cancers of different cellular or tissue origins express different ENOX2 cancer isoforms or combinations of isoforms and shed these proteins into the circulation. Herein are disclosed methods both for cancer detection and diagnosis of particular origin, based on the patterns and molecular weights of the isoforms which allow the identification of the cell type and or tissue of origin of the neoplasm. Relative ENOX2 amounts are proportional to tumor burden and provide a reliable measure of response to therapy and disease progression. Also provided is the amino acid sequence to which the scFv antibodies bind as the molecular basis for the specificity of the test.
