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UTILISATION D'INTERFERONS SUPERCOMPOSES DE RECOMBINAISON
专利权人:
WEI; GUANGWEN
发明人:
WEI, GUANGWEN
申请号:
CA2597317
公开号:
CA2597317C
申请日:
2006.03.09
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
This invention provides different uses of recombinant super-compoundinterferons (rSIFN-cos) and its equivalent with changed spatial configuration,high efficacy and low side effects. Therefore, high dose of rSIFN-co may beused. One characteristic of rSIFN-co is its ability to inhibit the HBV DNAduplication and secretion of HBsAg and HBeAg in in vitro pharmacologicalstudies. The cytotoxic effect of rSIFN-co is only one-eighth (1/8) ofcurrently clinically available interferons but its anti-viral effect isapproximately five to twenty (5-20) times higher, and when used in vivo it hasa broader spectrum of clinical applications and longer biofeedback response.This invention further provides super-compound interferon or its equivalent,synthesis of artificial gene with codon preference which codes for said rSIFN-co and its equivalent, vector comprising said gene and appropriate expressionsystem for expression of said rSIFN-co. Finally this invention provides thesuper-compound interferon (rSIFN-co) and its equivalent, a process to producesame and uses thereof .
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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