A system and method for assisting in a determination of one or more maladies associated with a human voice anatomy utilizes voice information acquired over at least two temporally displaced acquisitions. Acquired voice samples, including plural vowel sounds, are digitized and passed through one or more bandpass filters to isolate one or more frequency ranges. Curve fitting of acquired data is completed in accordance with a plurality of parameter weights applied in either a time domain or frequency domain model of the voice. This process is repeated a second, later time, for the same human, and the same process is completed for the subsequently-acquired voice information. A difference between the curve information in the respective data sets is analyzed relative to the weights, and corresponding changes are correlated to maladies of various areas of the human voice anatomy.