This invention has the same 3 D structure, PDGFR- , or - a join activity to domain outside the cell is, but itself the ni tonnage offers the component, or the other derivatives of peptide and its mutant which are not embodied. As for this peptide, SEQ ID NO: 1, 2 or 3 array is included. As for this invention furthermore, the tissue symptom, and the lung tissue symptom like the constituent, and the liver and the kidney of the nucleotide array which this peptide and its derivative the code is done, the primary cancer, and cancer transfer, the especially stomach cancer and the liver cancer, use of aforementioned peptide and the peptide derivative in preparing the medicine in order it prevents and to remedy the breast cancer, and the lung cancer and is offered.< Choice figure > Drawing 9本発明は、同じ3-D構造を有し、PDGFR-α、または-βの細胞外ドメインへの結合活性があるが、それ自体はニ量体化しないペプチド及びその変異体の成分、またはその他の誘導体を提供する。このペプチドは、SEQ ID NO:1、2または3の配列を含む。本発明はさらに、このペプチド及びその誘導体をコードするヌクレオチド配列の組成物、ならびに肝臓、腎のような線維症、及び肺線維症、原発性癌、及び癌転移、特に胃癌、肝臓癌、乳癌、及び肺癌を予防および治療するための医薬の調製における前記ペプチドおよびペプチド誘導体の使用を提供する。【選択図】 図9
