A method of preparing an antibody suitable for use in a feline is provided. Also provided are chimeric and felinized antibodies which specifically bind to feline neuronal growth factor (NGF) and neutralize the ability of feline NGF to bind to the p75 or TrkA feline NGF receptor. The invention extends to nucleic acids encoding same and to methods of treating pain and arthritis in a feline using said antibodies and/or nucleic acids.
