A regulator associated with expression of DNMT3A gene and application thereof are provided. The regulator regulates the expression of DNMT3A gene and can be the ingredient of pharmaceutical composition employed for treating diseases associated expression of DNMT3A gene and/or regulating phenomena associated expression of DNMT3A gene.本發明係關於一種與DNMT3A基因表現相關之調控物及其應用,該調控物促進或抑制DNMT3A基因的表現,且該調控物可作為用以治療與DNMT3A基因表現相關之疾病、及/或調控與DNMT3A基因表現相關之現象的醫藥組合物之成分。