Provided in the embodiments of the present disclosure are a control method and device based on brain signal, and a human-machine interaction device, which periodically acquire EEG signals and cerebral oxygen signals within a target period, generate an electroencephalogram (EEG) wave curve representing changes of the EEG signals and a cerebral oxygen wave curve representing changes of the cerebral oxygen signals respectively within the target period, determine whether the EEG wave curve and the cerebral oxygen wave curve satisfy a condition for controlling a controlled device to perform a target operation, and control the controlled device to perform the target operation when the EEG wave curve and the cerebral oxygen wave curve satisfy the condition.
